Synthesis of Controlled-Size Silica Nanoparticles from Sodium Metasilicate and the Effect of the Addition of PEG in the Size Distribution

被引:23
作者
Chapa-Gonzalez, Christian [1 ]
Laura Pinon-Urbina, Ana [1 ]
Elvia Garcia-Casillas, Perla [1 ]
机构
[1] Univ Autonoma Ciudad Juarez, Inst Ingn & Tecnol, Ave Charro 610, Cd Juarez 32310, Chihuahua, Mexico
关键词
silica nanoparticles; poly(ethylene glycol); ORMOSIL; biomedical applications; sodium metasilicate; SENSITIVE DETECTION; DRUG-DELIVERY; CELLS; CYTOTOXICITY; PACLITAXEL; SYSTEMS; ACID;
D O I
10.3390/ma11040510
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Silica nanoparticles are widely studied in emerging areas of nanomedicine because they are biocompatible, and their surface can be modified to provide functionalization. The size is intrinsically related to the performance of the silica nanoparticles; therefore, it is important to have control over the size. However, the silica nanoparticles obtained from sodium metasilicate are less studied than those obtained from tetraethyl orthosilicate. Moreover, the methods of surface modification involve several steps after the synthesis. In this work, the effect of different concentrations of sodium metasilicate on the size of silica nanoparticles was studied. In the same way, we studied the synthesis of organically modified silica nanoparticles in a one-step method, using poly(ethylene glycol). The nanoparticles were characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. It was found that the size distribution of the silica nanoparticles could be modified by changing the initial concentration of sodium metasilicate. The one-step surface-modification method caused a significant decrease in size distribution.
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页数:7
相关论文
共 24 条
[1]   Silica-based systems for oral delivery of drugs, macromolecules and cells [J].
Diab, Roudayna ;
Canilho, Nadia ;
Pavel, Ileana A. ;
Haffner, Fernanda B. ;
Girardon, Maxime ;
Pasc, Andreea .
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2017, 249 :346-362
[2]   Silica coated LSMO magnetic nanoparticles for the pH-Responsive delivery of 5-Fluorouracil anticancer drug [J].
Ehi-Eromosele, C. O. ;
Ita, B. I. ;
Iweala, E. E. J. .
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2017, 530 :164-171
[3]   Cellular imaging by green luminescence of Tb(III)-doped aminomodified silica nanoparticles [J].
Fedorenko, Svetlana V. ;
Mustafina, Asiya R. ;
Mukhametshina, Alsu R. ;
Jilkin, Michail E. ;
Mukhametzyanov, Timur A. ;
Solovieva, Anastasiya O. ;
Pozmogova, Tatiana N. ;
Shestopalova, Lidiya V. ;
Shestopalov, Michael A. ;
Kholin, Kirill V. ;
Osin, Yury N. ;
Sinyashin, Oleg G. .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 76 :551-558
[4]   Improving paclitaxel pharmacokinetics by using tumor-specific mesoporous silica nanoparticles with intraperitoneal delivery [J].
Fu, Qiang ;
Hargrove, Derek ;
Lu, Xiuling .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 12 (07) :1951-1959
[5]   Synthesis of hollow mesoporous silica (HMS) nanoparticles as a candidate for sulfasalazine drug loading [J].
Ghasemi, Sh. ;
Farsangi, Z. Jomeh ;
Beitollahi, A. ;
Mirkazemi, M. ;
Rezayat, S. M. ;
Sarkar, S. .
CERAMICS INTERNATIONAL, 2017, 43 (14) :11225-11232
[6]   Mesoporous silica nanoparticles as potential carriers for enhanced drug solubility of paclitaxel [J].
He, Yongju ;
Liang, Shuquan ;
Long, Mengqiu ;
Xu, Hui .
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 78 :12-17
[7]   Organically modified silica nanoparticles with covalently incorporated photosensitizer for photodynamic therapy of cancer [J].
Hulchanskyy, Tyrnish Y. ;
Roy, Indrajit ;
Goswami, Lalit N. ;
Chen, Yihui ;
Bergey, Earl J. ;
Pandey, Ravindra K. ;
Oseroff, Allan R. ;
Prasad, Paras N. .
NANO LETTERS, 2007, 7 (09) :2835-2842
[8]   Functional silica nanoparticles conjugated with beta-glucan to deliver anti-tuberculosis drug molecules [J].
Hwang, Jangsun ;
Son, Jaewoo ;
Seo, Youngmin ;
Jo, Yeonho ;
Lee, Kyungwoo ;
Lee, Dohyun ;
Khan, Muhammad Saad ;
Chavan, Sachin ;
Park, Chanhwi ;
Sharma, Anand ;
Gilad, Assaf A. ;
Choi, Jonghoon .
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2018, 58 :376-385
[9]  
Ingrid B., 2017, PHOTODIAGN PHOTODYN, V21, P275
[10]   Multifunctional mesoporous silica nanoparticles mediated co-delivery of paclitaxel and tetrandrine for overcoming multidrug resistance [J].
Jia, Lejiao ;
Li, Zhenyu ;
Shen, Jingyi ;
Zheng, Dandan ;
Tian, Xiaona ;
Guo, Hejian ;
Chang, Ping .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 489 (1-2) :318-330