A retrospective analysis of 165 patients who had diabetes mellitus and underwent percutaneous coronary intervention (PCI) between 1998 and 2003 demonstrated that those whose plasma glucose levels were greater than or equal to 200 mg/dl before PCI exhibited greater creatine phosphokinase release and serum creatinine increases after PCI. These observations identified hyperglycemia as a potentially modifiable mediator of myocardial and renal injuries in patients who have diabetes and have undergone PCI. (C) 2004 by Excerpta Medica, Inc.