The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

被引：53

作者：

Huigens, Robert W., III ^{[1
]}

Reyes, Samuel ^{[1
]}

Reed, Catherine S. ^{[1
]}

Bunders, Cynthia ^{[1
]}

Rogers, Steven A. ^{[1
]}

Steinhauer, Andrew T. ^{[1
]}

Melander, Christian ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 02期

关键词：

2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii; AERUGINOSA BIOFILM FORMATION; STAPHYLOCOCCUS-AUREUS; ACINETOBACTER-BAUMANNII; BACTERIAL BIOFILMS; DERIVATIVES; INHIBITION; MANAGEMENT; EMERGENCE; MILITARY; STRAINS;

D O I：

10.1016/j.bmc.2009.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (C) 2009 Published by Elsevier Ltd.

引用

页码：663 / 674

页数：12

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