Deoxypreussomerins from Jatropha curcas:: are they also plant metabolites?

被引:48
作者
Ravindranath, N [1 ]
Reddy, MR [1 ]
Mahender, G [1 ]
Ramu, R [1 ]
Kumar, KR [1 ]
Das, B [1 ]
机构
[1] Indian Inst Chem Technol, Organ Chem Div 1, Hyderabad 500007, Andhra Pradesh, India
关键词
Jatropha curcas; deoxypreussomerins; palmarumycins CP1; JC1 and JC2; X-ray analysis; antibacterial activity;
D O I
10.1016/j.phytochem.2004.06.032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three deoxypreussomerins, paimarumycins CP1, JC1 and JC2, have been isolated from a collection of the stems of Jatropha curcas. The second and third compounds are antibacterial constituents which were characterized from spectral evidence. The X-ray crystallographic structure of palmarumycin JC1 was also studied. Deoxypreussomerins have been obtained here from a plant source in appreciable quantities. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2387 / 2390
页数:4
相关论文
共 14 条
[1]   Unified route to the palmarumycin and preussomerin natural products. Enantioselective synthesis of (-)-preussomerin G [J].
Barrett, AGM ;
Blaney, F ;
Campbell, AD ;
Hamprecht, D ;
Meyer, T ;
White, AJP ;
Witty, D ;
Williams, DJ .
JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (09) :2735-2750
[2]  
Bode HB, 2000, EUR J ORG CHEM, V2000, P3185
[3]  
CONNOLLY JD, 1991, STUDIES NATURAL PROD, V9, P256
[4]   Biologically active metabolites from fungi.: Part 16:: New preussomerins J, K and L from an endophytic fungus:: structure elucidation, crystal structure analysis and determination of absolute configuration by CD calculations [J].
Krohn, K ;
Flörke, U ;
John, M ;
Root, N ;
Steingröver, K ;
Aust, HJ ;
Draeger, S ;
Schulz, B ;
Antus, S ;
Simonyi, M ;
Zsila, F .
TETRAHEDRON, 2001, 57 (20) :4343-4348
[5]  
KROHN K, 1994, LIEBIGS ANN CHEM, P1099
[6]  
KROHN K, 1994, LIEBIGS ANN CHEM, P1093
[7]   ISOLATION AND STRUCTURE DETERMINATION OF 4 NOVEL DITERPENES FROM JATROPHA-CURCUS [J].
NAENGCHOMNONG, W ;
THEBTARANONTH, Y ;
WIRIYACHITRA, P ;
OKAMOTO, KT ;
CLARDY, J .
TETRAHEDRON LETTERS, 1986, 27 (22) :2439-2442
[8]   The synthesis of 1,8-dihydroxynaphthalene-derived natural products:: palmarumycin CP1, palmarumycin CP2, palmarumycin C11, CJ-12,371, deoxypreussomerin A and novel analogues [J].
Ragot, JP ;
Steeneck, C ;
Alcaraz, ML ;
Taylor, RJK .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (08) :1073-1082
[9]   PREUSSOMERINS AND DEOXYPREUSSOMERINS - NOVEL INHIBITORS OF RAS FARNESYL-PROTEIN TRANSFERASE [J].
SINGH, SB ;
ZINK, DL ;
LIESCH, JM ;
BALL, RG ;
GOETZ, MA ;
BOLESSA, EA ;
GIACOBBE, RA ;
SILVERMAN, KC ;
BILLS, GF ;
PELAEZ, F ;
CASCALES, C ;
GIBBS, JB ;
LINGHAM, RB .
JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (21) :6296-6302
[10]   Sporovexins A-C and a new preussomerin analog:: Antibacterial and antifungal metabolites from the coprophilous fungus Sporormiella vexans [J].
Soman, AG ;
Gloer, JB ;
Koster, B ;
Malloch, D .
JOURNAL OF NATURAL PRODUCTS, 1999, 62 (04) :659-661