Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines

被引：23
|
作者：
Garlets, Zachary J. [1 ]
Silvi, Mattia [2 ]
Wolfe, John P. [1 ]
机构：
[1] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA
[2] ICIQ Inst Chem Res Catalonia, Ave Paisos Catalans 16, Tarragona 43007, Spain
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 10期
关键词：
CARBOAMINATION REACTIONS; SUBSTITUTED; 2-AMINOIMIDAZOLES; BICYCLIC GUANIDINES; NATURAL-PRODUCTS; NUCLEOPHILES; DERIVATIVES; NITROGEN; CARBODIIMIDES; HETEROCYCLES; CYCLIZATION;
D O I：
10.1021/acs.orglett.6b00598
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The silver-catalyzed hydroamination of tosylprotected N-allylguanidines is described. These reactions provide substituted cyclic guanidines in high yields. The reactions are amenable to the construction of quaternary stereocenters as well as both monocyclic and bicyclic guanidine products.
引用
收藏
页码：2331 / 2334
页数：4
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