Alkyl heterocycles in heterocyclic synthesis (II):: Novel synthesis of isoquinoline, thiazolopyridine, and thieno[2,3-b]pyridine derivatives

被引：4

作者：

Abu Elmaati, TM ^{[1
]}

机构：

[1] Mansoura Univ, Fac Appl Arts, Dept Text Printing & Dyeing, Dumyat, Egypt

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 06期

关键词：

D O I：

10.1002/jhet.5570410614

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treating 5 - (4-phenylcarboxamido)-3-cyano-4-methylpyridin-2(1H)thione (3) with elemental sulfur yielded thienopyridine 4. Compound 4 reacts with acrylonitrile to give isoquinoline 7. Compound 7 was also, prepared from 3 and methylenemalononitrile. Reaction of 3 with dimethylacetylene dicarboxylate (DMAD) gave the pyridothiazole 9. Also, 3 reacted with N,N-dimethylchloroacetamide (10) to afford compound 11 which further reacted with the reagents 12, 13 and 14 providing the thieno [2,3-b]pyridine derivatives 15, 16 and 17 respectively.

引用

页码：947 / 950

页数：4

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