A Prospective Study of Diurnal Cortisol and Incident Dementia in Community-Dwelling Older Adults

被引：1

作者：

Ancelin, Marie-Laure ^{[1
]}

Norton, Joanna ^{[1
]}

Scali, Jacqueline ^{[1
]}

Ritchie, Karen ^{[1
,2
]}

Chaudieu, Isabelle ^{[1
]}

Ryan, Joanne ^{[3
]}

机构：

[1] Univ Montpellier, INSERM, INM, Montpellier, France

[2] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland

[3] Monash Univ, Sch Publ Hlth & Prevent Med, Biol Neuropsychiat Unit, Melbourne, Vic, Australia

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 82卷 / 03期

基金：

英国医学研究理事会;

关键词：

Cortisol; dementia; hypothalamic-pituitary-adrenal axis; prospective study; stress; SALIVARY CORTISOL; DISEASE; HEALTH; AGE;

D O I：

10.3233/JAD-210389

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Diurnal salivary cortisol was measured in 334 older adults without dementia, at four times on two separate days, under quiet and stressful conditions. In multivariate Cox proportional hazard models, higher global diurnal cortisol secretion was associated with incident dementia (HR = 1.09 [1.02-1.15] per one-unit increase in cortisol measure, p = 0.007) and Alzheimer's disease (HR = 1.12 [1.04-1.21], p = 0.003) over a mean (SD) of 8.1 (4.0) years, independent of potential confounders and stressful conditions. Individuals with incident dementia had a slower rate of cortisol elimination under nonstressful conditions, reflected by higher cortisol levels in the evening, and an abnormal response to stress (blunted evening stress response).

引用

页码：899 / 904

页数：6

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