Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: IV. Generalized matrix analysis of linear compartment systems

被引：3

作者：

Langenbucher, F ^{[1
]}

机构：

[1] BioVista LLC, CH-4125 Riehen, Switzerland

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2005年 / 59卷 / 01期

关键词：

IVIVC; excel; systems analysis; pharmacokinetics; compartmental models;

D O I：

10.1016/j.ejpb.2004.07.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A linear system comprising)n compartments is completely defined by the rate constants between any of the compartments and the initial condition in which compartment(s) the drug is present at the beginning. The generalized solution is the time profiles of drug amount in each compartment, described by polyexponential equations. Based on standard matrix operations, an Excel worksheet computes the rate constants and the coefficients, finally the full time profiles for a specified range of time values. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：229 / 235

页数：7

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