Dementia with Lewy bodies and Alzheimer disease Neurodegenerative patterns characterized by DTI

被引：167

作者：

Kantarci, K. ^{[1
]}

Avula, R. ^{[1
]}

Senjem, M. L. ^{[1
]}

Samikoglu, A. R. ^{[1
]}

Zhang, B. ^{[1
,4
]}

Weigand, S. D. ^{[2
]}

Przybelski, S. A. ^{[2
]}

Edmonson, H. A. ^{[1
]}

Vemuri, P. ^{[1
]}

Knopman, D. S. ^{[3
]}

Ferman, T. J. ^{[5
]}

Boeve, B. F. ^{[3
]}

Petersen, R. C. ^{[3
]}

Jack, C. R., Jr. ^{[1
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[2] Mayo Clin, Div Biostat, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[4] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Radiol, Nanjing, Peoples R China

[5] Mayo Clin, Dept Psychiat & Psychol, Jacksonville, FL 32224 USA

来源：

NEUROLOGY | 2010年 / 74卷 / 22期

关键词：

MILD COGNITIVE IMPAIRMENT; MATTER TRACT INTEGRITY; PATHOLOGY; PROGRESSION; BRAINS; DAMAGE; MRI; DLB; AD;

D O I：

10.1212/WNL.0b013e3181e0f7cf

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To identify the patterns of diffusivity changes in patients with dementia with Lewy bodies (DLB) and Alzheimer disease (AD) and to determine whether diffusion tensor MRI (DTI) is complementary to structural MRI in depicting the tissue abnormalities characteristic of DLB and AD. Methods: We studied clinically diagnosed age-, gender-, and education-matched subjects with DLB (n = 30), subjects with AD (n = 30), and cognitively normal (CN) subjects (n = 60) in a case-control study. DTI was performed at 3T with a fluid-attenuated inversion recovery-based DTI sequence that enabled cortical diffusion measurements. Mean diffusivity (MD) and gray matter (GM) density were measured from segmented cortical regions. Tract-based diffusivity was measured using color-coded fractional anisotropy (FA) maps. Results: Patients with DLB were characterized by elevated MD in the amygdala and decreased FA in the inferior longitudinal fasciculus (ILF). ILF diffusivity was associated with the presence of visual hallucinations (p = 0.007), and amygdala diffusivity was associated with Unified Parkinson's Disease Rating Scale (r = 0.50; p = 0.005) in DLB. In contrast, patients with AD were characterized by elevated MD in the medial temporal, temporal, and parietal lobe association cortices and decreased FA in the fornix, cingulum, and ILF. Amygdala diffusivity was complementary to GM density in discriminating DLB from CN; hippocampal and parahippocampal diffusivity was complementary to GM density in discriminating AD from CN. Conclusion: Increased amygdalar diffusivity in the absence of tissue loss in dementia with Lewy bodies (DLB) may be related to microvacuolation, a common pathology associated with Lewy body disease in the amygdala. Diffusivity measurements were complementary to structural MRI, demonstrating that measures of diffusivity on diffusion tensor MRI are valuable tools for characterizing the tissue abnormalities characteristic of Alzheimer disease and DLB. Neurology(R) 2010;74:1814-1821

引用

页码：1814 / 1821

页数：8

共 40 条

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