The association of cytokine genes polymorphisms and susceptibility to aplastic anemia in Egyptian patients

被引：6
|
作者：
Zayed, Rania A. [1 ]
Abdel-Hamid, Samah M. [1 ]
El-Lithy, Hend [2 ]
机构：
[1] Cairo Univ, Kasralainy Fac Med, Clin & Chem Pathol Dept, Cairo, Egypt
[2] Cairo Univ, Kasralainy Fac Med, Dept Internal Med, Cairo, Egypt
来源：
HEMATOLOGY | 2016年 / 21卷 / 02期
关键词：
Aplastic anemia; Cytokine gene polymorphism; TGF-beta; 1-509; C/T; TNF-alpha-308; G/A; IFN-gamma+874 A/T; NECROSIS-FACTOR-ALPHA; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; SINGLE NUCLEOTIDE POLYMORPHISM; MARROW T-LYMPHOCYTES; GROWTH-FACTOR-BETA; BONE-MARROW; INTERFERON-GAMMA; IMMUNOSUPPRESSIVE THERAPY; PROGENITOR CELLS; FLOW-CYTOMETRY;
D O I：
10.1179/1607845415Y.0000000038
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and objective: Aplastic anemia (AA) remains a rare disease, with very interesting pathophysiology that is being investigated for years now. The present study aimed to determine the association between cytokine gene polymorphisms (TGF-beta 1 -509 C/T, TNF-alpha -308 G/A, IFN-gamma + 874 A/T) and susceptibility to AA in Egyptian patients. Methods: The study included 80 participants subjected to determination of gene polymorphisms on genomic DNA using polymerase chain reaction-restriction fragment length polymorphism assay. Results: It was found that IFN-gamma + 874 A/T gene polymorphism is associated with three-fold increased risk of development of AA (odds ratio (OR) 3.116, P = 0.019), while TNF-alpha -308 G/A gene polymorphism is associated with decreased risk (OR 0.318, P = 0.026). TGF-beta 1 -509 C/T gene polymorphism showed comparable risk between patients and controls (P = 0.263). Conclusion: IFN-gamma + 874 A/T gene polymorphism is associated with the etiology of AA in Egyptian patients.
引用
收藏
页码：106 / 112
页数：7
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