Copper-Catalyzed Asymmetric Propargylation of Indolizines

被引：32
|
作者：
Yang, Lei [1 ,2 ,3 ]
Pu, Xiang [1 ,2 ,3 ]
Niu, Dawen [1 ,2 ,3 ]
Fu, Zhengyan [1 ,2 ,3 ]
Zhang, Xia [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, State Key Lab Biotherapy, Dept Emergency, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Canc Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, Sch Chem Engn, Chengdu 610041, Sichuan, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 21期
关键词：
ENANTIOSELECTIVE PROPARGYLATION; ESTERS; SUBSTITUTION; ALKYLATION; AMINATION; DEAROMATIZATION; ETHERIFICATION; CYCLOADDITION; CONSTRUCTION; ACETATES;
D O I：
10.1021/acs.orglett.9b03032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methods to diversify indolizines are valuable for the discovery of medications and fluorescent molecules. The utilization of copper-catalyzed asymmetric propargylation to install a terminal alkyne handle on indolizine heterocycle is reported. This method delivers C3-propargylation products from C2-substituted indolizines or C1-propargylation products from C2,C3-disubstituted indolizines through a stereoconvergent pathway.
引用
收藏
页码：8553 / 8557
页数：5
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