How to introduce MSC-based therapy for the developing lung safely into clinical care?

被引：5

作者：

Ruediger, Mario ^{[1
,2
]}

Kirpalani, Haresh ^{[3
]}

Steinhorn, Robin ^{[4
,5
]}

Davis, Jonathan M. ^{[6
,7
]}

Thebaud, Bernard ^{[8
,9
]}

机构：

[1] Tech Univ Dresden, Saxony Ctr Feto Neonatal Hlth, Dresden, Germany

[2] Tech Univ Dresden, Ctr Regenerat Therapies CRTD, Univ Klinikum Dresden, Dept Neonatol & Pediat Intens Care Med,Univ Kinde, Dresden, Germany

[3] Univ Penn, Dept Pediat, Childrens Hosp Philadelphia, Div Neonatol, Philadelphia, PA 19104 USA

[4] Childrens Natl Hosp, Washington, DC USA

[5] George Washington Univ, Washington, DC USA

[6] Tufts Univ, Dept Pediat, Floating Hosp Children, Tufts Med Ctr, Boston, MA 02111 USA

[7] Tufts Univ, Tufts Clin & Translat Sci Inst, Boston, MA 02111 USA

[8] Univ Ottawa, Dept Pediat, Div Neonatol, CHEO, Ottawa, ON, Canada

[9] Univ Ottawa, CHEO Res Inst, Sinclair Ctr Regenerat Med, Ottawa Hosp Res Inst,Dept Cellular & Mol Med, Ottawa, ON, Canada

来源：

PEDIATRIC RESEARCH | 2020年 / 88卷 / 03期

关键词：

MESENCHYMAL STEM-CELLS; UMBILICAL-CORD BLOOD; BRONCHOPULMONARY DYSPLASIA; STROMAL CELLS; DUCTUS-ARTERIOSUS; PREMATURE-INFANTS; PRETERM INFANTS; CLOSURE;

D O I：

10.1038/s41390-020-0758-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Extreme prematurity is associated with an increased risk to develop bronchopulmonary dysplasia (BPD). Severe BPD is associated with a significant long-term burden for the affected infant, families and society. Currently there are limited prevention and treatment options. Regenerative approaches using mesenchymal stromal cells (MSC) are associated with promising benefits in animal experiments. First clinical studies, using MSC in humans, suggest safety. To accelerate the process of bench to bed-side development of MSC-based therapies, a global and collaborative approach is needed that includes all key stakeholders. Results of a workshop that was held during the Pediatric Academic Societies meeting in 2019 are summarized. A roadmap is provided discussing next steps of bringing MSC-based interventions into clinical practice.

引用

页码：365 / 368

页数：4

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