Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

被引：28
作者：
Chen, Wan-Yu [1 ,2 ,3 ,12 ]
Wu, Chen-Tu [4 ,5 ,6 ]
Wang, Chun-Wei [1 ,3 ,7 ]
Lan, Keng-Hsueh [1 ,3 ,12 ]
Liang, Hsiang-Kuang [1 ,3 ,12 ]
Huang, Bing-Shen [9 ,10 ]
Chang, Yih-Leong [4 ,5 ,6 ]
Kuo, Sung-Hsin [1 ,3 ,8 ,11 ,12 ]
Cheng, Ann-Lii [3 ,8 ,11 ,12 ]
机构：
[1] Natl Taiwan Univ Hosp, Div Radiat Oncol, Dept Oncol, 7 Chung Shan South Rd, Taipei 100, Taiwan
[2] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan
[3] Natl Taiwan Univ, Canc Res Ctr, Coll Med, Taipei, Taiwan
[4] Natl Taiwan Univ, Grad Inst Pathol, Coll Med, Taipei, Taiwan
[5] Natl Taiwan Univ Hosp, Dept Pathol, 7 Chung Shan South Rd, Taipei 10002, Taiwan
[6] Natl Taiwan Univ, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan
[7] Natl Taiwan Univ, Dept Radiol, Coll Med, Taipei, Taiwan
[8] Natl Taiwan Univ, Grad Inst Oncol, Coll Med, Taipei, Taiwan
[9] Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan, Taiwan
[10] Chang Gung Univ, Taoyuan, Taiwan
[11] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan
[12] Natl Taiwan Univ, Canc Ctr, Coll Med, Taipei, Taiwan
来源：
RADIATION ONCOLOGY | 2018年 / 13卷
关键词：
Tongue cancer; Head neck cancer; Adjuvant; Tumor-infiltrating lymphocytes; Prognosis; SQUAMOUS-CELL CARCINOMA; T-CELLS; OROPHARYNGEAL CANCER; COLORECTAL-CANCER; NECK-CANCER; SURVIVAL; HEAD; PREDICT; IMPACT;
D O I：
10.1186/s13014-018-1099-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods: The presence of CD3(+), CD4(+), CD8(+), and forkhead box protein P3-positive (FOXP3(+)) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results: The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p = 0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p = 0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p = 0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions: In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.
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页数：8
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