2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants

被引：156

作者：

Douxfils, Jonathan ^{[1
,2
]}

Adcock, Dorothy M. ^{[3
]}

Bates, Shannon M. ^{[4
]}

Favaloro, Emmanuel J. ^{[5
]}

Gouin-Thibault, Isabelle ^{[6
]}

Guillermo, Cecilia ^{[7
]}

Kawai, Yohko ^{[8
]}

Lindhoff-Last, Edelgard ^{[9
]}

Kitchen, Steve ^{[10
]}

Gosselin, Robert C. ^{[11
]}

机构：

[1] Univ Namur, Dept Pharm, Namur Thrombosis & Hemostasis Ctr, Namur, Belgium

[2] Qualiblood SA, Namur, Belgium

[3] Lab Corp Amer, Burlington, NC USA

[4] McMaster Univ, Dept Med, Med Ctr, Hamilton, ON, Canada

[5] Westmead Hosp, Sydney Ctr Haemostasis & Thrombosis, Dept Haematol, Inst Clin Pathol & Med Res,NSW Hlth Pathol, Westmead, NSW, Australia

[6] Univ Hosp, IRSET INSERM 1085, Dept Hematol Hemostasis, Rennes, France

[7] Univ Republica, Fac Med, Hosp Clin Dr Manuel Quintela, Montevideo, Uruguay

[8] Sanno Hosp, Lab Med, Tokyo, Japan

[9] CCB Coagulat Ctr, CCB Vasc Ctr, Cardiol Angiol Ctr Bethanien, Frankfurt, Germany

[10] Royal Hallamshire Hosp, Coagulat Sheffield, Sheffield, S Yorkshire, England

[11] Univ Calif Davis, Davis Hlth Syst, Hemophilia Treatment Ctr, Sacramento, CA USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2021年 / 121卷 / 08期

关键词：

diagnosis management; guidance; direct oral anticoagulants; laboratory; DOAC STOP; VENOUS THROMBOEMBOLISM; DABIGATRAN REVERSAL; ANDEXANET ALPHA; IN-VITRO; RIVAROXABAN; HEMOSTASIS; SURGERY; IDARUCIZUMAB; MANAGEMENT;

D O I：

10.1055/a-1450-8178

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2018, the International Council for Standardization in Haematology (ICSH) published a consensus document providing guidance for laboratories on measuring direct oral anticoagulants (DOACs). Since that publication, several significant changes related to DOACs have occurred, including the approval of a new DOAC by the Food and Drug Administration, betrixaban, and a specific DOAC reversal agent intended for use when the reversal of anticoagulation with apixaban or rivaroxaban is needed due to life-threatening or uncontrolled bleeding, andexanet alfa. In addition, this ICSH Working Party recognized areas where additional information was warranted, including patient population considerations and updates in point-of-care testing. The information in this manuscript supplements our previous ICSH DOAC laboratory guidance document. The recommendations provided are based on (1) information from peer-reviewed publications about laboratory measurement of DOACs, (2) contributing author's personal experience/expert opinion and (3) good laboratory practice.

引用

页码：1008 / 1020

页数：13

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