SYNTHESIS OF N, N-DIALKYL PHOSPHORAMIDIC DICHLORIDE FROM DIALKYL AMINE AND PHOSPHORYL CHLORIDE USING BASIC ANION EXCHANGE POLYMER RESINS/BEADS

被引：0
|
作者：
Kushwaha, Brijesh K. [1 ]
Gupta, Hemendra K. [2 ]
Shinde, C. P. [1 ]
机构：
[1] Jiwaji Univ, SOS Chem, Gwalior 474002, India
[2] Def R&D Estab, Gwalior 474002, India
来源：
HETEROCYCLIC COMMUNICATIONS | 2009年 / 15卷 / 05期
关键词：
Nerve agents; phosphoramidic dichloride; solid support;
D O I：
10.1515/HC.2009.15.5.361
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and operationally simple method is developed for the synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In the reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.
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收藏
页码：361 / 364
页数：4
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