Visit-to-Visit Blood Pressure Variability and Alzheimer's Disease: Links and Risks

被引：54

作者：

Nagai, Michiaki ^{[1
]}

Dote, Keigo ^{[1
]}

Kato, Masaya ^{[1
]}

Sasaki, Shota ^{[1
]}

Oda, Noboru ^{[1
]}

Kagawa, Eisuke ^{[1
]}

Nakano, Yoshinori ^{[1
]}

Yamane, Aya ^{[1
]}

Higashihara, Tasuku ^{[1
]}

Miyauchi, Shunsuke ^{[1
]}

Tsuchiya, Akane ^{[1
]}

机构：

[1] Hiroshima City Asa Hosp, Dept Cardiol, Hiroshima, Japan

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 59卷 / 02期

关键词：

Alzheimer's disease; amyloid beta; cognitive impairment; hypertension; visit-to-visit blood pressure variability; WHITE-MATTER LESIONS; PULSE-WAVE VELOCITY; COGNITIVE FUNCTION; ARTERIAL STIFFNESS; MOUSE MODEL; CARDIOVASCULAR-DISEASE; INDEPENDENT DETERMINANTS; EPISODIC HYPERTENSION; ELDERLY ASSOCIATIONS; BAROREFLEX FUNCTION;

D O I：

10.3233/JAD-161172

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While hypertension has been shown to be a risk factor for vascular dementia, several studies have also demonstrated that hypertension also increases the risk of Alzheimer's disease (AD). Although the relationship between visit-to-visit blood pressure variability (VVV) and cognitive impairment, including AD, have been provided, the mechanisms remain poorly understood. This review paper focuses on the relationship of VVV with AD and summarizes the pathophysiology underlying that relationship, which appears to be mediated by arterial stiffness.

引用

页码：515 / 526

页数：12

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