The role of the cell surface glycocalyx in drug delivery to and through the endothelium

被引:23
作者
Fu, Lu [1 ]
Kim, Ha Na [1 ]
Sterling, James D. [2 ]
Baker, Shenda M. [3 ]
Lord, Megan S. [1 ]
机构
[1] UNSW Sydney, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
[2] Keck Grad Inst, Riggs Sch Appl Life Sci, 535 Watson Dr, Claremont, CA 91711 USA
[3] Synedgen Inc, 1420 N Claremont Blvd,Suite 105, Claremont, CA 91711 USA
基金
澳大利亚研究理事会;
关键词
Endothelium; Vascular system; Glycocalyx; Glycosaminoglycan; Drug delivery system; Biomaterial; HEPARAN-SULFATE PROTEOGLYCANS; IRON-OXIDE NANOPARTICLES; LEUKOCYTE ADHESION; SHEAR-STRESS; VASCULAR-PERMEABILITY; CARBOHYDRATE LIGAND; PROTEIN CORONA; P-SELECTIN; IN-VITRO; INFLAMMATION;
D O I
10.1016/j.addr.2022.114195
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cell membranes are key interfaces where materials engineering meets biology. Traditionally regarded as just the location of receptors regulating the uptake of molecules, we now know that all mammalian cell membranes are 'sugar coated'. These sugars, or glycans, form a matrix bound at the cell membrane via proteins and lipids, referred to as the glycocalyx, which modulate access to cell membrane receptors crucial for interactions with drug delivery systems (DDS). Focusing on the key blood-tissue barrier faced by most DDS to enable transport from the place of administration to target sites via the circulation, we critically assess the design of carriers for interactions at the endothelial cell surface. We also discuss the current challenges for this area and provide opportunities for future research efforts to more fully engineer DDS for controlled, efficient, and targeted interactions with the endothelium for therapeutic application. (c) 2022 Elsevier B.V. All rights reserved.
引用
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页数:15
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