Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa

被引：15

作者：

Matsumoto, Takahiro ^{[1
]}

Nakamura, Seikou ^{[1
]}

Fujimoto, Katsuyoshi ^{[1
]}

Ohta, Tomoe ^{[1
]}

Ogawa, Keiko ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

Onishi, Eri ^{[1
]}

Fukaya, Masashi ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Pharmacognosy, Yamashina Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2015年 / 69卷 / 01期

关键词：

Curcuma comosa; Diarylheptanoids; Antiallergic activity; Thai traditional medicine; HISTAMINE-RELEASE INHIBITORS; FLOWER BUDS; MEDICINAL FOODSTUFFS; TRITERPENE SAPONINS; CANANGA-ODORATA; TNF-ALPHA; CONSTITUENTS; PRINCIPLES; DEGRANULATION; REQUIREMENTS;

D O I：

10.1007/s11418-014-0870-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit the release of beta-hexosaminidase as a maker of degranulation from rat basophil leukemia (RBL-2H3) cells. Two new diarylheptanoids, diarylcomosols IV and V, were isolated from the methanolic extract. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The isolated diarylheptanoids showed inhibitory activity, and the structural requirements of the active constituents for the inhibition were clarified.

引用

页码：142 / 147

页数：6

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