Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade

被引：97

作者：

Giampieri, Francesca ^{[1
]}

Alvarez-Suarez, Jose M. ^{[1
,2
]}

Cordero, Mario D. ^{[3
]}

Gasparrini, Massimiliano ^{[1
]}

Forbes-Hernandez, Tamara Y. ^{[1
,4
]}

Afrin, Sadia ^{[1
]}

Santos-Buelga, Celestino ^{[5
]}

Gonzalez-Paramas, Ana M. ^{[5
]}

Astolfi, Paola ^{[6
]}

Rubini, Corrado ^{[7
]}

Zizzi, Antonio ^{[7
]}

Tulipani, Sara ^{[8
,9
]}

Quiles, Jose L. ^{[10
]}

Mezzetti, Bruno ^{[11
]}

Battino, Maurizio ^{[1
,12
]}

机构：

[1] Univ Politecn Marche, Fac Med, Sez Biochim, Dipartimento Sci Clin Specialist & Odontostolog D, Via Ranieri 65, I-60131 Ancona, Italy

[2] Univ Las Amer UDLA, Fac Ciencias Salud, Escuela Med Vet & Zootecnia, Jose Queri 170125, Quito, Ecuador

[3] Univ Seville, Oral Med Dept, Res Lab, C Avicena S-N, E-41009 Seville, Spain

[4] Univ Internac Iberoamericana UNINI, Area Nutr & Salud, Calle 15, Campeche 24560, Mexico

[5] Univ Salamanca, Fac Pharm, Grp Invest Polifenoles GIP USAL, Campus Miguel de Unamuno, E-37007 Salamanca, Spain

[6] Univ Politecn Marche, Dipartimento Sci Ingn Mat Ambiente & Urbanist, Via Brecce Bianche, I-60131 Ancona, Italy

[7] Univ Politecninca Marche, Dipartimento Sci Biomed & Sanita Pubbl, Sez Anat Patolog, Via Conca 71, I-60126 Ancona, Italy

[8] Univ Barcelona, Pharm & Food Sci Fac, Biomarkers & Nutrimetabol Lab, Nutr Ev Food Sci Dept,XaRTA,INSA, Campus Torribera, E-08028 Barcelona, Spain

[9] Biomed Res Inst IBIMA, Serv Endocrinol & Nutr, Malaga Hosp Complex Virgen de la Victoria, Malaga, Spain

[10] Univ Granada, Ctr Invest Biomed, Dept Fisiol, Inst Nutr & Tecnol Alimentos Jose Mataix, Granada 18100, Spain

[11] Univ Politecn Marche, Dipartimento Sci Agrarie Alimentari & Ambiental, Via Ranieri 65, I-60131 Ancona, Italy

[12] UEA, Ctr Nutr & Hlth, C Isabel Torres 21, Santander 39011, Spain

来源：

FOOD CHEMISTRY | 2017年 / 234卷

基金：

欧盟地平线“2020”;

关键词：

AMPK activation; Aging; Oxidative stress; Mitochondrial functionality; Strawberry polyphenols; IN-VIVO; SUPPLEMENTATION; ANTHOCYANINS; HEALTH; GROWTH;

D O I：

10.1016/j.foodchem.2017.05.017

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging associated reductions in mitochondrial function and biogenesis for 8 weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P < 0.05). Furthermore, a significant (P < 0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：464 / 471

页数：8

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