Determination of Octanol-Water Partition Coefficient by Normal Phase TLC: A New Simple Method to Adopt for Graduate Laboratory Practical

被引：0

作者：

Jatan, Shah, V ^{[1
]}

Dipen, Purohit A. ^{[1
]}

Nishit, Basera A. ^{[1
]}

Dhaval, Sojitra ^{[1
]}

Sathish, N. K. ^{[2
]}

Gowramma, B. ^{[1
]}

Kumar, Prashantha B. R. ^{[1
]}

机构：

[1] JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, Tamil Nadu, India

[2] Bharathi Coll Pharm, Dept Pharmaceut Chem, Mandya 571422, Karnataka, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2009年 / 43卷 / 04期

关键词：

Partition coefficient; Thin layer chromatography; logP; ORGANIC-COMPOUNDS; CHROMATOGRAPHY; LIPOPHILICITY;

D O I：

暂无

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Owing to the importance of partition coefficient in the filed of pharmaceutical education and research, in the present work we have made an attempt to determine the octanol/water partition coefficient (logP) values for drugs by a simple normal phase TLC technique. The illustration about the developed method, its accuracy, its applicability and comparison with that of the reported and calculated values by using various computational softwares are described in this paper.

引用

页码：365 / 369

页数：5

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