Determination of Octanol-Water Partition Coefficient by Normal Phase TLC: A New Simple Method to Adopt for Graduate Laboratory Practical

被引：0

作者：

Jatan, Shah, V ^{[1
]}

Dipen, Purohit A. ^{[1
]}

Nishit, Basera A. ^{[1
]}

Dhaval, Sojitra ^{[1
]}

Sathish, N. K. ^{[2
]}

Gowramma, B. ^{[1
]}

Kumar, Prashantha B. R. ^{[1
]}

机构：

[1] JSS Coll Pharm, Dept Pharmaceut Chem, Ootacamund 643001, Tamil Nadu, India

[2] Bharathi Coll Pharm, Dept Pharmaceut Chem, Mandya 571422, Karnataka, India

来源：

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2009年 / 43卷 / 04期

关键词：

Partition coefficient; Thin layer chromatography; logP; ORGANIC-COMPOUNDS; CHROMATOGRAPHY; LIPOPHILICITY;

D O I：

暂无

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Owing to the importance of partition coefficient in the filed of pharmaceutical education and research, in the present work we have made an attempt to determine the octanol/water partition coefficient (logP) values for drugs by a simple normal phase TLC technique. The illustration about the developed method, its accuracy, its applicability and comparison with that of the reported and calculated values by using various computational softwares are described in this paper.

引用

页码：365 / 369

页数：5

共 13 条

[1] Potentiometric determination of octanol-water and liposome-water partition coefficients (logP) of ionizable organic compounds [J].

Barzanti, Claire ;

Evans, Rebecca ;

Fouquet, Jeremy ;

Gouzin, Leonard ;

Howarth, Nicola M. ;

Kean, Gary ;

Levet, Emilie ;

Wang, Daniel ;

Wayemberg, Estelle ;

Yeboah, Agnes A. ;

Kraft, Arno .

TETRAHEDRON LETTERS, 2007, 48 (19) :3337-3341

[2]

BECKETT AH, 2005, TXB PRACTICAL PHAR 2, P115

[3] Determination of gas-liquid partition coefficients by gas chromatography [J].

Castells, RC .

JOURNAL OF CHROMATOGRAPHY A, 2004, 1037 (1-2) :223-231

[4]

DENNIS AS, 2001, PHARMACOKINETICS MET

[5] CORRELATIONS BETWEEN LIQUID-CHROMATOGRAPHIC CAPACITY RATIO DATA ON LICHROSORB-RP-18 AND PARTITION-COEFFICIENTS IN THE OCTANOL WATER-SYSTEM [J].

HAMMERS, WE ;

MEURS, GJ ;

DELIGNY, CL .

JOURNAL OF CHROMATOGRAPHY, 1982, 247 (01) :1-13

[6] Lipophilicity and pKa estimates from gradient high-performance liquid chromatography [J].

Kaliszan, R ;

Haber, P ;

Baczek, T ;

Siluk, D ;

Valko, K .

JOURNAL OF CHROMATOGRAPHY A, 2002, 965 (1-2) :117-127

[7] PARTITION COEFFICIENTS AND THEIR USES [J].

LEO, A ;

HANSCH, C ;

ELKINS, D .

CHEMICAL REVIEWS, 1971, 71 (06) :525-+

[8]

MARIA FM, 2005, CARBOHYD RES, V340, P1207

[9]

REKKER RF, 1979, EUR J MED CHEM, V14, P479

[10] OCTANOL-WATER PARTITION-COEFFICIENTS OF SIMPLE ORGANIC-COMPOUNDS [J].

SANGSTER, J .

JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA, 1989, 18 (03) :1111-1229

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