Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery

被引：89

作者：

Chen, Ganchao ^{[1
,4
]}

Xie, Yusheng ^{[1
,4
]}

Peltier, Raoul ^{[1
,4
]}

Lei, Haipeng ^{[1
,4
]}

Wang, Ping ^{[1
,4
]}

Chen, Jun ^{[5
]}

Hu, Yi ^{[5
]}

Wang, Feng ^{[2
]}

Yao, Xi ^{[3
]}

Sun, Hongyan ^{[1
,4
]}

机构：

[1] City Univ Hong Kong, Dept Biol & Chem, 83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[2] City Univ Hong Kong, Dept Phys & Mat Sci, 83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Dept Biomed Sci, 83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[4] City Univ Hong Kong, Shenzhen Res Inst, Biotech & Hlth Ctr, Key Lab Biochip Technol, Shenzhen 518057, Peoples R China

[5] Chinese Acad Sci, Inst High Energy Phys, Multidisciplinary Res Div, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 18期

基金：

中国国家自然科学基金;

关键词：

peptides; gold nanoparticles; charge reversal; targeted delivery; controlled release; CONTROLLED-RELEASE; MICELLES; PRODRUG; CELLS;

D O I：

10.1021/acsami.6b02594

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A stimuli-responsive drug delivery system (DDS) with bioactive surface is constructed by end-capping mesoporous silica nanoparticles (MSNs) with functional peptide-coated gold nanoparticles (GNPs). MSNs are first functionalized with acid-labile alpha-amide-beta-carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo-lysine-containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to alpha(v)beta(3) integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.

引用

页码：11204 / 11209

页数：6

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