Prolonged QT interval and sudden infant death - report of two cases

被引:10
作者
Bajanowski, T
Rossi, L
Biondo, B
Ortmann, C
Haverkamp, W
Wedekind, H
Jorch, G
Brinkmann, B
机构
[1] Univ Munster, Inst Legal Med, D-48149 Munster, Germany
[2] Univ Milan, Inst Pathol, I-20121 Milan, Italy
[3] Univ Milan, Inst Pathol, I-20122 Milan, Italy
[4] Univ Munster, Med Klin & Poliklin Innere Med Kardiol Angiol C, D-48149 Munster, Germany
[5] Univ Magdeburg, Klin Allgemeine Padiat & Neonatol, D-39120 Magdeburg, Germany
关键词
long QT syndrome; sudden infant death; cardiac conduction system; genetics;
D O I
10.1016/S0379-0738(00)00325-X
中图分类号
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号
0301 ; 10 ;
摘要
In the two cases where infants died suddenly and unexpectedly the electrocardiogram (ECG) of a younger sibling (case 1) and of a living twin (case 2) led to the suspicion that the two infants could have died from long QT syndrome (LQTS). In case 1, a His bundle (HB) dispersion and a pronounced hypoplasia of the right external nucleus arcuatus were detected. In case 2, a severe interstitial pneumonia and an accompanying mild myocarditis were found by histology. Molecular genetic investigations of the coding regions of the genes, HERG, KVLQT1 and SCN5A gave no indication for the mutations, thus, affecting related myocardial ion channels as possible sources of inhomogeneity of repolarisation. Since a molecular genetic deviation could not yet be elaborated the possible role of related disturbance remains unknown. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:147 / 153
页数:7
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