Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent

被引：6
|
作者：
Cheon, SH
Park, JS
Chung, BH
Choi, BG
Cho, WJ
Choi, SU
Lee, CO
机构：
[1] Chonnam Natl Univ, Coll Pharm, Buk Ku, Kwangju 500757, South Korea
[2] Korea Res Inst Chem Technol, Screening & Toxicol Res Ctr, Taejon 305606, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 02期
基金：
新加坡国家研究基金会;
关键词：
isoquinolin-1-ones; antitumor; bioisostere;
D O I：
10.1007/BF02974027
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidazo[2,1 -a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[4'-(piperidinomethyl) phenyl]-2,3-dihydroimidazo [2,1-a]isoquinoline (1).
引用
收藏
页码：193 / 197
页数：5
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