Structure of a Putative Fluorinated Natural Product from Streptomyees sp TC1

被引：13

作者：

Aldemir, Hueya ^{[1
,2
]}

Kohlhepp, Stefanie V. ^{[3
]}

Gulder, Tanja ^{[3
]}

Gulder, Tobias A. M. ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Biosyst Chem, Dept Chem, D-85747 Garching, Germany

[2] Tech Univ Munich, CIPSM, D-85747 Garching, Germany

[3] Tech Univ Munich, Dept Chem, D-85747 Garching, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 11期

关键词：

MECHANISM; SALINOSPORAMIDE; ORGANOFLUORINE; BIOSYNTHESIS; ANTIOXIDANTS; ACCUMULATION; ENZYME;

D O I：

10.1021/np500643g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fluorine-containing natural products are extremely rare. The recent report on the isolation and biological activity of the bacterial secondary metabolite 3-(3,5-di-tert-butyl-4-fluorophenyl)propionic acid was thus highly remarkable. The compound contained the first aromatic fluorine substituent known to date in any natural product. The promise to discover an enzyme capable of aromatic fluorination in the producing strain Streptomyces sp. TC1 prompted our immediate interest. A close inspection of the originally reported analytical data of the fluoro metabolite revealed inconsistencies that triggered us to validate the reported structure. The results of these efforts are presented in this communication.

引用

页码：2331 / 2334

页数：4

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