Cobalt-Catalyzed Oxidative C(sp3)-H Phosphonylation for α-Aminophosphonates via C(sp3)-H/P(O)-H Coupling

被引：59

作者：

Lin, Binzhou ^{[1
,2
]}

Shi, Shanshan ^{[1
,2
]}

Lin, Rongcan ^{[1
,2
]}

Cui, Yiqun ^{[1
,2
]}

Fang, Meijuan ^{[3
]}

Tang, Guo ^{[1
,2
]}

Zhao, Yufen ^{[1
,2
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361000, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 12期

关键词：

C-H BONDS; TERTIARY-AMINES; EFFICIENT; AIR; PHOSPHONATION; COMPLEX; SYSTEM;

D O I：

10.1021/acs.joc.8b00674

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first oxidative C(sp(3))-H phosphonylation of tertiary aliphatic amines has been developed. The use of cobalt acetate as a catalyst, N-hydroxyphthalimide as a cocatalyst, and air as an oxidant enabled the conversion of tertiary aromatic and aliphatic amines into alpha-aminophosphonates in moderate to excellent yields under mild conditions via a cross dehydrogenative coupling reaction.

引用

收藏

页码：6754 / 6761

页数：8

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