The role of histone lysine methyltransferase NSD3 in cancer

被引：24

作者：

Han, Xu ^{[1
]}

Piao, Lianhua ^{[2
]}

Zhuang, Qianfeng ^{[1
]}

Yuan, Xiaofeng ^{[3
]}

Liu, Zhiwei ^{[3
]}

He, Xiaozhou ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 3, Dept Urol, 185 Juqian St, Changzhou 213003, Jiangsu, Peoples R China

[2] Jiangsu Univ Technol, Inst Bioinformat & Med Engn, Changzhou, Jiangsu, Peoples R China

[3] Soochow Univ, Affiliated Hosp 3, Dept Orthopaed, Changzhou, Jiangsu, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2018年 / 11卷

基金：

美国国家科学基金会;

关键词：

NSD3; cancer; carcinogenesis; MIDLINE CARCINOMA; BREAST-CANCER; METHYLATION; WHSC1L1; PROTEIN; FAMILY; GENE; AMPLIFICATION; EXPRESSION; AMPLICON;

D O I：

10.2147/OTT.S166006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The growing number of findings demonstrate that nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax domain-containing 3 (NSD3) is amplified and overexpressed in multiple cancer types. Nevertheless, the biological roles of NSD3 in carcinogenesis have not been well understood. In this review, we summarize the current knowledge on the mechanisms underlying NSD3 regulation in different cancers. In addition, NSD3 may serve as a potential druggable target for selective cancer therapy in the future.

引用

页码：3847 / 3852

页数：6

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