Nanocomposite Materials Developed from Nano-hydroxyapatite Impregnated Chitosan/κ-Carrageenan for Bone Tissue Engineering.

被引：13
作者：
Zia, Iram [1 ]
Jolly, Reshma [1 ]
Mirza, Sumbul [1 ]
Rehman, Abdur [2 ]
Shakir, Mohammad [1 ]
机构：
[1] Aligarh Muslim Univ, Dept Chem, Inorgan Chem Lab, Aligarh 202002, India
[2] Aligarh Muslim Univ, Dept Zool, Aligarh 202002, India
来源：
CHEMISTRYSELECT | 2022年 / 7卷 / 03期
关键词：
bone tissue engineering; chitosan; & kappa; -carrageenan; nanoparticle; polymers; IN-VITRO; POLYELECTROLYTE COMPLEX; POROUS SCAFFOLDS; COMPOSITE; FABRICATION; CHITOSAN; NANOENSEMBLE; HYDROGELS; DELIVERY;
D O I：
10.1002/slct.202103234
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, nano-hydroxyapatite impregnated chitosan/?-carrageenan (nHAp/CHI/?-CGN) nanocomposite was prepared through co-precipitation approach and was compared with nano-hydroxyapatite/chitosan (nHAp/CHI) nanocomposite for bone regeneration capability. The comparative assessment carried out through Scanning electron microscopy, Fourier transform infra-red spectroscopy, X-ray diffraction and mechanical testing revealed rough surface morphology, better interaction between the components, favorable crystallinity, and higher mechanical properties for the nHAp/CHI/?-CGN nanocomposite as compared to the bicomponent nanocomposite. Moreover, the in vitro biomineralization study showed increased deposition of apatite layer on nHAp/CHI/?-CGN nanocomposite as compared to nHAp/CHI nanocomposite. The cytocompatibility studies carried out using the MG-63 cell line revealed greater cell viability when cultured in the presence of nHAp/CHI/?-CGN nanocomposite as compared to nHAp/CHI. In addition, appropriate swelling ability, enhanced protein adsorption, and favorable degradation rate were also observed for the nHAp/CHI/?-CGN nanocomposite. All the results substantiate that nHAp/CHI/?-CGN nanocomposite could be a better candidate for bone regeneration.
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页数：10
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