Red cell aplasia in children on tacrolimus after liver transplantation

被引：38

作者：

Misra, S

Moore, TB

Ament, ME

Busuttil, RW

McDiarmid, SV

机构：

[1] Univ Calif Los Angeles, Med Ctr, Dept Pediat, Div Pediat Gastroenterol & Nutr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90095 USA

[4] Oregon Hlth Sci Univ, Div Pediat Hematol Oncol, Stem Cell Transplant Program, Portland, OR 97201 USA

[5] Univ Calif Los Angeles, Dept Surg Liver & Pancreas Transplantat, Los Angeles, CA 90095 USA

来源：

TRANSPLANTATION | 1998年 / 65卷 / 04期

关键词：

D O I：

10.1097/00007890-199802270-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematological toxicity of tacrolimus has been rarely reported. We report two pediatric recipients of liver transplantation with anemia. They were treated with tacrolimus for 8 and 47 months, respectively, before developing pure red cell aplasia (PRCA) confirmed by bone marrow biopsy. The children recovered quickly on withdrawal of tacrolimus. The clinical profile of these children is compared with the only other patient reported in the literature with PRCA due to tacrolimus. All three patients had similar hematological findings. However, the mechanism of the tacrolimus-induced PRCA in these children appears to be different from that reported in the adult patient.

引用

页码：575 / 577

页数：3

共 7 条

[1]

CHERRICK I, 1994, AM J PEDIAT HEMATOL, V16, P320

[2]

COOPER MH, 1994, BONE MARROW TRANSPL, V14, P355

[3]

HIRAO A, 1993, BLOOD, V81, P79

[4]

Jacobs P, 1995, Dis Mon, V41, P201

[5] TACROLIMUS - A REVIEW OF ITS PHARMACOLOGY, AND THERAPEUTIC POTENTIAL IN HEPATIC AND RENAL-TRANSPLANTATION [J].

PETERS, DH ;

FITTON, A ;

PLOSKER, GL ;

FAULDS, D .

DRUGS, 1993, 46 (04) :746-794

[6] Pure red cell aplasia induced by FK506 [J].

Suzuki, S ;

Osaka, Y ;

Nakai, I ;

Yasumura, T ;

Omori, Y ;

Yamagata, N ;

Shimazaki, C ;

Oka, T .

TRANSPLANTATION, 1996, 61 (05) :831-832

[7] Enhancing and suppressive effects of immunosuppressants cyclosporin A, FK506, and KM2210 on the colony formation of murine bone marrow cells [J].

Zhu, X ;

Imamura, M ;

Hashino, S ;

Tanaka, J ;

Kobayashi, S ;

Tao, HR ;

Asaka, M ;

Kasai, M ;

Matsudaira, T ;

Asano, S .

ANNALS OF HEMATOLOGY, 1995, 71 (06) :301-306

← 1 →