PLATISIDINES A-C, N-METHYLPYRIDINIUM ALKALOIDS FROM AN OKINAWAN MARINE SPONGE OF PLAKORTIS SPECIES

被引：12

作者：

Kubota, Takaaki ^{[1
]}

Ishiguro, Yuichiro ^{[1
]}

Yamamoto, Sunao ^{[1
]}

Fromont, Jane ^{[2
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

HETEROCYCLES | 2010年 / 80卷 / 02期

关键词：

Sponge; Plakortis species; Pyridinium Alkaloid; Platisidines A-C; Acetylcholinesterase Inhibitor; MANZAMENONES; SIMPLEX; ACID;

D O I：

10.3987/COM-09-S(S)131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new N-methyl pyridinium alkaloids, platisidines A-C (1-3), were isolated from an Okinawan marine sponge of the genus Plakortis, and the structures were elucidated from spectroscopic data. The structures of platisidines A-C (1-3) were elucidated to be N-methyl nicotinic acid derivatives with a n-hexadecanoyl chain. Platisidines A-C (1-3) showed inhibitory activity against acetylcholinesterase.

引用

页码：1407 / 1412

页数：6

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