Development and validation of an LC-MS/MS method for the simultaneous determination of bedaquiline and rifabutin in human plasma

被引：10

作者：

Gray, Wesley A. ^{[1
,4
]}

Waldorf, Byron ^{[1
]}

Rao, Manasa Geeta ^{[1
,5
]}

Stiles, Brenda L. ^{[2
]}

Griffiss, J. McLeod ^{[2
]}

Salata, Robert A. ^{[3
]}

Blumer, Jeffrey L. ^{[1
,6
]}

机构：

[1] Univ Toledo, Dept Pediat, 3000 Arlington Ave, Toledo, OH 43614 USA

[2] ICON Govt & Publ Hlth Solut, Clin Res Management, 1265 Ridge Rd, Hinckley, OH 44233 USA

[3] Case Western Reserve Univ, Dept Med, 10900 Euclid Ave, Cleveland, OH 44106 USA

[4] Smithers RAPRA, 426 South Main St, Akron, OH 44311 USA

[5] Yale Univ, New Haven, CT 06520 USA

[6] 20 West Juniper Lane, Moreland Hills, OH 44022 USA

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2019年 / 176卷

基金：

美国国家卫生研究院;

关键词：

Bedaquiline; TMC-207; Rifabutuin; Bedaquiline metabolite M2; 25-O-Desacetylrifabutin; Mycobacterium tuberculosis; Stable isotope dilution tandem mass spectrometry; ATP SYNTHASE; DIARYLQUINOLINES;

D O I：

10.1016/j.jpba.2019.07.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This article describes the simultaneous determination of bedaquiline fumarate (TMC-207) and rifabutin in human plasma by stable isotope dilution tandem mass spectrometry. The methodology was developed for an investigation of potential drug-drug interactions of the two anti-tuberculosis drugs when given together to healthy human volunteers. Use of the two drugs in combination to treat disease caused by Mycobacterium tuberculosis is contemplated as the bacterium becomes resistant to many currently available drugs. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：8

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