Advances in in-situ product recovery (ISPR) in whole cell biotechnology during the last decade

被引：122

作者：

Van Hecke, Wouter ^{[1
]}

Kaur, Guneet ^{[1
]}

De Wever, Heleen ^{[1
]}

机构：

[1] Flemish Inst Technol Res VITO, Business Unit Separat & Convers Technol, B-2400 Mol, Belgium

来源：

BIOTECHNOLOGY ADVANCES | 2014年 / 32卷 / 07期

基金：

欧盟第七框架计划;

关键词：

In-situ product recovery (ISPR); ISPR-coupled whole-cell bioprocess; Microbial biotransformations; ACETONE-BUTANOL-ETHANOL; 2-PHASE PARTITIONING BIOREACTOR; LACTIC-ACID FERMENTATION; RECOMBINANT ESCHERICHIA-COLI; NEAR-INFRARED SPECTROSCOPY; SOLID-LIQUID TPPBS; CLOSTRIDIUM-ACETOBUTYLICUM; EXTRACTIVE FERMENTATION; FED-BATCH; ENHANCED BIOPRODUCTION;

D O I：

10.1016/j.biotechadv.2014.07.003

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10 years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1245 / 1255

页数：11

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