Variants Associated with Susceptibility to Pancreatic Cancer and Melanoma Do Not Reciprocally Affect Risk

被引：12

作者：

Wu, Lang ^{[1
]}

Goldstein, Alisa M. ^{[2
]}

Yu, Kai ^{[2
]}

Yang, Xiaohong Rose ^{[2
]}

Rabe, Kari G. ^{[1
]}

Arslan, Alan A. ^{[3
,4
]}

Canzian, Federico ^{[6
]}

Wolpin, Brian M. ^{[5
]}

Stolzenberg-Solomon, Rachael ^{[2
]}

Amundadottir, Laufey T. ^{[2
]}

Petersen, Gloria M. ^{[1
]}

机构：

[1] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[2] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[3] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA

[4] NYU, Sch Med, Dept Environm Med, New York, NY USA

[5] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[6] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2014年 / 23卷 / 06期

关键词：

GENOME-WIDE ASSOCIATION; LOCI;

D O I：

10.1158/1055-9965.EPI-13-0627

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Melanoma cases may exist in pancreatic cancer kindreds, whereas there is increased risk of pancreatic cancer in familial melanoma. The two cancers may share genetic susceptibility variants in common. Methods: Three dbGaP (datasets in Genotypes and Phenotypes)-deposited GWAS (genome-wide association study) datasets (MD Anderson melanoma, PanScan 1, and PanScan 2 for pancreatic cancer) were used. Thirty-seven melanoma susceptibility variants in 22 genomic regions from published GWAS, plus melanoma-related genes and pathways were examined for pancreatic cancer risk in the PanScan datasets. Conversely, nine known pancreatic cancer susceptibility variants were examined for melanoma risk in the MD Anderson dataset. Results: In the PanScan data, initial associations were found with melanoma susceptibility variants in NCOA6 [rs4911442; OR, 1.32; 95% confidence interval (CI), 1.03-1.70; P = 0.03], YWHAZP5 (rs17119461; OR, 2.62; 95% CI, 1.08-6.35; P = 0.03), and YWHAZP5(rs17119490; OR, 2.62; 95% CI, 1.08-6.34; P = 0.03), TYRP1 (P = 0.04), and IFNA13 (P = 0.04). In the melanoma dataset, two pancreatic cancer susceptibility variants were associated: NR5A2 (rs12029406; OR, 1.39; 95% CI, 1.01-1.92; P = 0.04) and CLPTM1L-TERT (rs401681; OR, 1.16; 95% CI, 1.01-1.34; P = 0.04). None of these associations remained significant after correcting for multiple comparisons. Conclusion: Reported variants of melanoma genes and pathways do not play a role in pancreatic cancer predisposition. Reciprocally, pancreatic cancer susceptibility variants are not associated with melanoma risk. Impact: Known melanoma-related genes and pathways, as well as GWAS-derived susceptibility variants of melanoma and pancreatic cancer, do not explain the shared genetic etiology of these two cancers. (C) 2014 AACR.

引用

页码：1121 / 1124

页数：4

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