Bis(indoline-2,3-diones):Versatile precursors for novel bis(2′,6′-dimethyl-2-oxo-1′H-spiro[indoline-3,4′-pyridine]-3′,5′-dicarbonitrile) derivatives

被引:19
作者
Abdelmoniem, Amr M. [1 ]
Elwahy, Ahmed H. M. [1 ]
Abdelhamid, Ismail A. [1 ]
机构
[1] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
关键词
Bis(indoline-2,3-diones); bis(spirooxindole); 1,4-dihydropyridine-3,5-dicarbonitrile; alkylation; condensation; SUBSTITUTED MACROCYCLIC LIGANDS; AZAENAMINES; CATALYST;
D O I
10.3998/ark.5550190.0017.324
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Reaction of 3-aminocrotononitrile with a series of bis(indoline-2,3-diones) afforded the corresponding bis(2',6'-dimethyl-2-oxo-1'H-spiro[indoline-3,4'-pyridine]-3', 5'-dicarbonitrile) derivatives in good to excellent yields.
引用
收藏
页码:304 / 312
页数:9
相关论文
共 33 条
[1]   Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms [J].
Abbas, Hebat-Allah S. ;
El Sayed, Wael A. ;
Fathy, Nahed M. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (03) :973-982
[2]   DBU-Catalyzed, facile and efficient method for synthesis of spirocyclic 2-oxindole derivatives with incorporated 6-amino-4H-pyridazines and fused derivatives via [3+3] atom combination [J].
Abdelhamid, Ismail A. ;
Mohamed, Mona H. ;
Abdelmoniem, Amr M. ;
Ghozlan, Said A. S. .
TETRAHEDRON, 2009, 65 (48) :10069-10073
[3]   Synthesis and biological evaluation of novel 2,4′-bis substituted diphenylamines as anticancer agents and potential epidermal growth factor receptor tyrosine kinase inhibitors [J].
Abou-Seri, Sahar Mahmoud .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :4113-4121
[4]   4-ARYLDIHYDROPYRIDINES, A NEW CLASS OF HIGHLY-ACTIVE CALCIUM-ANTAGONISTS [J].
BOSSERT, F ;
MEYER, H ;
WEHINGER, E .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1981, 20 (09) :762-769
[5]   Efficient One-Pot Synthesis of Novell Spirooxindole Derivatives via Three-Component Reaction in Aqueous Medium [J].
Chen, Hui ;
Shi, Daqing .
JOURNAL OF COMBINATORIAL CHEMISTRY, 2010, 12 (04) :571-576
[6]   The chemistry of isatins: a review from 1975 to 1999 [J].
da Silva, JFM ;
Garden, SJ ;
Pinto, AC .
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2001, 12 (03) :273-324
[7]   SPECIFIC AGGREGATION OF SV40-TRANSFORMED CELLS BY ORNITHINE,LEUCINE COPOLYMERS [J].
DUKSIN, D ;
KATCHALSKI, E ;
SACHS, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (01) :185-+
[8]   Total synthesis of spirotryprostatin A, leading to the discovery of some biologically promising analogues [J].
Edmondson, S ;
Danishefsky, SJ ;
Sepp-Lorenzino, L ;
Rosen, N .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (10) :2147-2155
[9]   Bis(β-difunctional) compounds:: Versatile starting materials for novel bis(heterocycles) [J].
Elwahy, AHM ;
Abbas, AA .
SYNTHETIC COMMUNICATIONS, 2000, 30 (16) :2903-2921
[10]   Synthesis of new benzo-substituted macrocyclic ligands containing pyridine or triazole as subcyclic units [J].
Elwahy, AHM ;
Abbas, AA .
TETRAHEDRON, 2000, 56 (06) :885-895