Study of Hydroquinone Mediated Cytotoxicity and Hypopigmentation Effects from UVB-Irradiated Arbutin and DeoxyArbutin

被引：21

作者：

Chang, Nai-Fang ^{[1
]}

Chen, Yi-Shyan ^{[1
]}

Lin, Ying-Ju ^{[2
,3
]}

Tai, Ting-Hsuan ^{[1
]}

Chen, An-Ni ^{[1
]}

Huang, Chen-Hsuan ^{[1
]}

Lin, Chih-Chien ^{[1
]}

机构：

[1] Providence Univ, Dept Cosmet Sci, 200,Sec 7,Taiwan Blvd, Taichung 43301, Taiwan

[2] China Med Univ Hosp, Dept Med Res, 2 Yuh Der Rd, Taichung 40447, Taiwan

[3] China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期

关键词：

arbutin; deoxyArbutin; hydroquinone; UVB-irradiation; cytotoxicity; hypopigmentation; TYROSINASE INHIBITION; TRANSCRIPTION FACTOR; MELANOGENESIS; DERIVATIVES; CELLS; ACID;

D O I：

10.3390/ijms18050969

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arbutin (Arb) and deoxyArbutin (dA) are both effective hypopigmentation agents. However, they are glucoside derivatives of hydroquinone (HQ), which may be decayed into HQ under higher energy environments. Therefore, safety and toxicity are very important issues when considering the usage of these compounds. However, no study has verified the properties of Ultra-Violet B (UVB)-irradiated Arb and dA. In this work, we investigated the cytotoxicity and hypopigmentation effects of UVB-irradiated Arb and dA in Detroit 551 human fibroblast cells and B16-F10 mouse melanoma cells. The results showed that UVB-irradiated Arb and dA have strong cytotoxicity for the fibroblast cells, especially for dA, the caspase-3 is also activated by the treatment of UVB-irradiated dA in Detroit 551 cells. The results correlated with the produced HQ. In addition, UVB-irradiated Arb and dA suppressed the production of melanin in melanoma cells; this is due to the release of HQ that compensates for the UVB triggered Arb and dA decomposition.

引用

页数：10

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