The Effect of Bowman-Birk Inhibitor from Soybeans on the Sensitivity of Prostate Cancer Stem-like Cells to Anti-androgen Agent

被引：1
|
作者：
Endo, Daiki [1 ]
Kaneko, Saki [1 ]
Ishii, Kyota [2 ]
Kohno, Kakeru [1 ,3 ]
Sato, Ayami [3 ]
Virgona, Nantiga [3 ]
Yano, Tomohiro [1 ,2 ,3 ]
机构：
[1] Toyo Univ, Grad Sch Food & Nutr Sci, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan
[2] Fac Food & Nutr Sci, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan
[3] Toyo Univ, Inst Life Innovat Studies, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan
来源：
FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2020年 / 26卷 / 04期
关键词：
Bowman-Birk inhibitor; androgen; anti-androgen agent; prostate cancer stem cell; prostate-specific antigen;
D O I：
10.3136/fstr.26.553
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Prostate stem-like cells exhibit resistance to anti-androgen agents and contribute to the recurrence of this cancer. A novel approach to overcome the resistance of prostate cancer stem-like cells is thus essential. The present study investigated whether soybean derived Bowman-Birk inhibitor (BBI) could abrogate the resistance of prostate cancer stem-like cells from an androgen-dependent prostate cancer cell line (LNCaP cells) to an anti-androgen agent. The LNCaP stem-like cells exhibited stronger resistance to an androgen antagonist, flutamide, than LNCaP parental cells. Exposure of LNCaP stem-like cells to BBI treatment reduced their stemness and resistance to flutamide. In parallel, LNCaP stem-like cells showed a positive response based on changes in the typical androgen-governed gene, prostate-specific antigen. These results suggest the potential of BBI as a candidate to reduce the resistance of prostate cancer stem-like cells to antiandrogen agents.
引用
收藏
页码：553 / 559
页数：7
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