The Effect of Bowman-Birk Inhibitor from Soybeans on the Sensitivity of Prostate Cancer Stem-like Cells to Anti-androgen Agent

被引：1

作者：

Endo, Daiki ^{[1
]}

Kaneko, Saki ^{[1
]}

Ishii, Kyota ^{[2
]}

Kohno, Kakeru ^{[1
,3
]}

Sato, Ayami ^{[3
]}

Virgona, Nantiga ^{[3
]}

Yano, Tomohiro ^{[1
,2
,3
]}

机构：

[1] Toyo Univ, Grad Sch Food & Nutr Sci, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan

[2] Fac Food & Nutr Sci, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan

[3] Toyo Univ, Inst Life Innovat Studies, 1-1-1 Izumino,Itakura Machi, Oura, Gunma 3740193, Japan

来源：

FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2020年 / 26卷 / 04期

关键词：

Bowman-Birk inhibitor; androgen; anti-androgen agent; prostate cancer stem cell; prostate-specific antigen;

D O I：

10.3136/fstr.26.553

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Prostate stem-like cells exhibit resistance to anti-androgen agents and contribute to the recurrence of this cancer. A novel approach to overcome the resistance of prostate cancer stem-like cells is thus essential. The present study investigated whether soybean derived Bowman-Birk inhibitor (BBI) could abrogate the resistance of prostate cancer stem-like cells from an androgen-dependent prostate cancer cell line (LNCaP cells) to an anti-androgen agent. The LNCaP stem-like cells exhibited stronger resistance to an androgen antagonist, flutamide, than LNCaP parental cells. Exposure of LNCaP stem-like cells to BBI treatment reduced their stemness and resistance to flutamide. In parallel, LNCaP stem-like cells showed a positive response based on changes in the typical androgen-governed gene, prostate-specific antigen. These results suggest the potential of BBI as a candidate to reduce the resistance of prostate cancer stem-like cells to antiandrogen agents.

引用

页码：553 / 559

页数：7

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