Coupling a DNA-ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols

被引：32
|
作者：
Cao, Fangfang [1 ,2 ,3 ]
Ju, Enguo [1 ,2 ,3 ]
Liu, Chaoqun [1 ,2 ,3 ]
Pu, Fang [1 ,2 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resources Utilizat, Changchun 130022, Jilin, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 29期
基金：
中国国家自然科学基金;
关键词：
PERFORMANCE LIQUID-CHROMATOGRAPHY; FLUORESCENT SILVER NANOCLUSTERS; SELECTIVE DETECTION; GOLD NANOPARTICLES; SENSITIVE DETECTION; AMINO-ACIDS; CYSTEINE; GLUTATHIONE; HOMOCYSTEINE; PROBE;
D O I：
10.1039/c5cc10606k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have demonstrated the synthesis of a smart nanoprobe by coupling a DNA-ligand ensemble with Ag cluster formation that allows the label-free and ratiometric detection of intracellular biothiols with high sensitivity and selectivity as well as discrimination of normal cells and cancer cells.
引用
收藏
页码：5167 / 5170
页数：4
相关论文
共 27 条
  • [1] A label-free fluorimetric detection of biothiols based on the oxidase-like activity of Ag+ ions
    Li, Ru
    Lei, Cuihua
    Zhao, Xian-En
    Gao, Yue
    Gao, Han
    Zhu, Shuyun
    Wang, Hua
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2018, 188 : 20 - 25
  • [2] Modulating an in situ fluorogenic reaction for the label-free ratiometric detection of biothiols
    Zhang, Haiqing
    Xiao, Yan
    Zhang, Xiuhua
    Wang, Shengfu
    ANALYST, 2019, 144 (15) : 4520 - 4525
  • [3] A label-free ratiometric electrochemical DNA sensor for monitoring intracellular redox homeostasis
    Liu, Xinping
    Yan, Zhengqing
    Sun, Yuhuan
    Ren, Jinsong
    Qu, Xiaogang
    CHEMICAL COMMUNICATIONS, 2017, 53 (46) : 6215 - 6218
  • [4] Double-strand DNA-templated synthesis of copper nanoclusters as novel fluorescence probe for label-free detection of biothiols
    Hu, Yihui
    Wu, Yanmei
    Chen, Tingting
    Chu, Xia
    Yu, Ruqin
    ANALYTICAL METHODS, 2013, 5 (14) : 3577 - 3581
  • [5] Label-Free Detection of Ag+ Based on Gold Nanoparticles and Ag+-Specific DNA
    Pu, Wendan
    Zhao, Zhao
    Wu, Liping
    Liu, Yue
    Zhao, Huawen
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2015, 15 (08) : 5524 - 5529
  • [6] Novel electrochemiluminescence of silver nanoclusters fabricated on triplex DNA scaffolds for label-free detection of biothiols
    Feng, Lingyan
    Wu, Li
    Xing, Feifei
    Hu, Lianzhe
    Ren, Jinsong
    Qu, Xiaogang
    BIOSENSORS & BIOELECTRONICS, 2017, 98 : 378 - 385
  • [7] Conformational switching of G-quadruplexes as a label-free platform for the fluorescence detection of Ag+ and biothiols
    Yang, Xiaoli
    Wei, Wei
    Jiang, Jianhui
    Shen, Guoli
    Yu, Ruqin
    ANALYTICAL METHODS, 2016, 8 (02) : 311 - 315
  • [8] Ag Nanoparticle-decorated graphene quantum dots for label-free, rapid and sensitive detection of Ag+ and biothiols
    Ran, Xiang
    Sun, Hanjun
    Pu, Fang
    Ren, Jinsong
    Qu, Xiaogang
    CHEMICAL COMMUNICATIONS, 2013, 49 (11) : 1079 - 1081
  • [9] A novel ratiometric fluorescence nanoprobe based on aggregation-induced emission of silver nanoclusters for the label-free detection of biothiols
    Zhou, Jie
    Xiao, Yan
    Zhang, Xiuhua
    Wang, Shengfu
    TALANTA, 2018, 188 : 623 - 629
  • [10] A label-free biosensor for DNA detection based on ligand-responsive G-quadruplex formation
    Guo, Yahui
    Xu, Pei
    Hu, Hui
    Zhou, Xiaodong
    Hu, Jiming
    TALANTA, 2013, 114 : 138 - 142
123