Primary Central Nervous System Lymphoma

被引：20

作者：

Sinicrope, Kaylyn ^{[1
]}

Batchelor, Tracy ^{[1
,2
,3
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, 55 Fruit St, Boston, MA 02114 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Radiat Oncol, 55 Fruit St, Boston, MA 02114 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Div Hematol & Oncol, 55 Fruit St, Boston, MA 02114 USA

来源：

NEUROLOGIC CLINICS | 2018年 / 36卷 / 03期

关键词：

Primary central nervous system lymphoma; Brain; Non-Hodgkin's lymphoma; Methotraxate; PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; STEM-CELL TRANSPLANTATION; WHOLE-BRAIN RADIOTHERAPY; NON-HODGKINS-LYMPHOMA; MULTICENTER PHASE-II; INTERNATIONAL EXTRANODAL LYMPHOMA; RECURRENT PRIMARY CNS; LONG-TERM SURVIVAL; DEFERRED RADIOTHERAPY;

D O I：

10.1016/j.ncl.2018.04.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary central nervous system lymphoma (PCNSL) is an aggressive form of non-Hodgkin lymphoma restricted to the central nervous system. Stereotactic biopsy is the gold standard for diagnosis of PCNSL. Extent of disease evaluation for patients with newly diagnosed PCNSL includes brain imaging, eye examination, cerebrospinal fluid assessment, body imaging, and bone marrow biopsy. Methotrexate-based chemotherapy is the standard induction for patients with PCNSL. Optimal consolidation therapy for PCNSL has not been defined, with several options feasible, including chemotherapy, high-dose chemotherapy, and autologous stem cell transplantation or whole-brain radiation therapy. Optimal treatment for relapsed and refractory PCNSL has not been defined.

引用

页码：517 / +

页数：17

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