Convenient methods for the synthesis of ferrocene-carbohydrate conjugates

被引：128
作者：
Casas-Solvas, JM
Vargas-Berenguel, A [1 ]
Capitán-Vallvey, LF
Santoyo-González, F
机构：
[1] Univ Almeria, Area Quim Organ, Almeria 04120, Spain
[2] Univ Granada, Dept Quim Analit, Fac Ciencias, E-18071 Granada, Spain
[3] Univ Granada, Inst Biotecnol, Fac Ciencias, E-18071 Granada, Spain
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 21期
关键词：
D O I：
10.1021/ol048665j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report two methods for the attachment of mono- and disaccharides to one or both of the cyclopentadienyl rings in ferrocene. The first strategy involves the reaction in acidic media of thioglycosides with ferrocenemethanol or 1,1'-ferrocenedimethanol. The second method consists of the regiospecific catalytic cycloaddition of propargyl glycoside and azidomethyl and bis(azidomethyl)ferrocene leading to the 1,2,3-triazole derivatives. The inverse strategy was also explored. The electrochemical behavior of the synthesized ferrocene-containing glycoconjugates was investigated.
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页码：3687 / 3690
页数：4
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