The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells

被引：11
作者：
Yamasaki, Masao [1 ]
Soda, Shozen [1 ]
Sakakibara, Yoichi [1 ]
Suiko, Masahito [1 ]
Nishiyama, Kazuo [1 ]
机构：
[1] Miyazaki Univ, Fac Agr, Dept Biochem & Appl Biosci, Miyazaki 88921, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 11期
关键词：
alpha-lipoic acid; invasion; migration; beta; 1-integrin; bladder cancer cells; APOPTOSIS; REDUCTASE;
D O I：
10.1080/09168451.2014.943647
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here, we show that cell surface beta 1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by alpha-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the action of alpha-lipoic acid.
引用
收藏
页码：1939 / 1942
页数：4
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