Functionalization of silica nanoparticles for nucleic acid delivery

被引：42
作者：
Kamegawa, Rimpei [1 ]
Naito, Mitsuru [2 ]
Miyata, Kanjiro [1 ]
机构：
[1] Univ Tokyo, Grad Sch Engn, Dept Mat Engn, Tokyo 1138656, Japan
[2] Univ Tokyo, Grad Sch Med, Ctr Dis Biol & Integrat Med, Tokyo 1130033, Japan
来源：
NANO RESEARCH | 2018年 / 11卷 / 10期
基金：
日本科学技术振兴机构; 日本学术振兴会;
关键词：
silica nanoparticle; mesoporous silica; silica coating; nucleic acid; drug delivery; TARGETED DRUG-DELIVERY; RESPONSIVE GENE DELIVERY; SUPPORTED LIPID-BILAYERS; EFFICIENT SIRNA DELIVERY; SMALL INTERFERING RNA; IN-VITRO; INTRACELLULAR DELIVERY; CANCER-THERAPY; BREAST-CANCER; ANTISENSE OLIGONUCLEOTIDES;
D O I：
10.1007/s12274-018-2116-7
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Silica nanoparticles (SiNPs) have been widely engineered for biomedical applications, such as bioimaging and drug delivery, because of their high tunability, which allows them to perform specific functions. In this review, we discuss the functionalization and performance of SiNPs for nucleic acid delivery. Nucleic acids, including plasmid DNA (pDNA) and small interfering RNA (siRNA), constitute the next generation molecular drugs for the treatment of intractable diseases. However, their low bioavailability requires delivery systems that can circumvent nuclease attack and kidney filtration to ensure efficient access to the target cell cytoplasm or nucleus. First, we discussed the biological significance of nucleic acids and the parameters required for their successful delivery. Next, we reviewed SiNP designing for nucleic acid delivery with respect to nucleic acid loading and release, cellular uptake, endosomal escape, and biocompatibility. In addition, we discussed the co-delivery potential of SiNPs. Finally, we analyzed the current challenges and future directions of SiNPs for advanced nucleic acid delivery.
引用
收藏
页码：5219 / 5239
页数：21
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