Factors associated with antihypertensive medication non-adherence: a systematic review

被引:87
作者
van der Laan, D. M. [1 ,2 ]
Elders, P. J. M. [2 ,3 ]
Boons, C. C. L. M. [1 ]
Beckeringh, J. J. [4 ]
Nijpels, G. [2 ,3 ]
Hugtenburg, J. G. [1 ,2 ,3 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Clin Pharmacol & Pharm, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Gen Practice & Elderly Care Med, Amsterdam, Netherlands
[4] Westwijk Pharmaceut BV, Kamillelaan 1, Amstelveen, Netherlands
关键词
LONG-TERM MEDICATION; HYPERTENSIVE PATIENTS; DEPRESSIVE SYMPTOMS; RISK INDICATORS; ADHERENCE; PREDICTORS; THERAPY; PROVIDER; BARRIERS; BELIEFS;
D O I
10.1038/jhh.2017.48
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Non-adherence to antihypertensive medication is the most important cause of uncontrolled blood pressure and is influenced by multiple interrelating factors. Understanding the complexity of medication non-adherence and its associated factors is important to determine intervention strategies. Therefore, a systematic review was performed aimed to identify factors associated with antihypertensive medication non-adherence. Different databases were searched for observational studies reporting on factors associated with non-adherence to antihypertensive medication. Titles, abstracts and full texts were reviewed by three researchers. Subsequently, the methodological quality of each study was assessed. Factors that were extracted from the included studies were categorised as factors with consistent or inconsistent evidence to put their potential importance into perspective. Forty-four studies were included. Higher co-payment, side effects and a poor patient-provider relationship were identified as factors with consistent evidence since consistent significant relationships were found for these factors whenever studied. The relationships between non-adherence and multiple other factors were inconsistent among the reviewed studies. However, some of these factors deserve some consideration. Since multiple potentially relevant factors were identified, patient-tailored interventions focussing on identifying and addressing patients' specific barriers to adherence are needed. Further research should clarify the influence of inconsistent factors on adherence and their potential to be addressed in interventions.
引用
收藏
页码:687 / 694
页数:8
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