Examination of Folate-Targeted Liposomes with Encapsulated Poly(2-propylacrylic acid) as a pH-Responsive Nanoplatform for Cytosolic Drug Delivery

被引：9

作者：

Cheng, Zhiliang ^{[1
]}

Chen, Antony K. ^{[1
]}

Lee, Ha-Young ^{[1
]}

Tsourkas, Andrew ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

SMALL | 2010年 / 6卷 / 13期

关键词：

drug delivery; encapsulation; liposomes pH response; receptors; INTRACELLULAR DELIVERY; PEPTIDE; NANOPARTICLES; OLIGONUCLEOTIDES; FORMULATION; MOLECULES; POLYMERS; VESICLES; CHITOSAN; RELEASE;

D O I：

10.1002/smll.201000347

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cells are incubated with folate-targeted liposomes formed in the presence or absence of poly(2-propylacrylic acid) (PPAA). The pH-responsive nature of liposomes with encapsulated PPAA allows for the efficient delivery of membrane-impermeable molecules, such as anticancer drugs, into the cytosol of living cells. (Figure Presented.) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1398 / 1401

页数：4

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