Catalyst-Free α-Aminoxylation of 1,3-Dicarbonyl Compounds with TEMPO Using Selectfluor as an Oxidant

被引：6

作者：

Tang, Lin ^{[1
]}

Yang, Zhen ^{[1
]}

Yang, Fang ^{[1
]}

Huang, Yifan ^{[1
]}

Chen, Hanfei ^{[1
]}

Cheng, Hao ^{[1
]}

Song, Weiyan ^{[1
]}

Ren, Bo ^{[1
]}

Zhou, Qiuju ^{[1
]}

机构：

[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Xinyang 464000, Peoples R China

来源：

CHEMISTRYSELECT | 2019年 / 4卷 / 41期

基金：

中国国家自然科学基金;

关键词：

catalyst-free; alpha-aminoxylation; 1; 3-dicarbonyl compounds; Selectfluor; C-O bond formation; C-H BOND; ELECTROPHILIC FLUORINATION; ENANTIOSELECTIVE SYNTHESIS; OXYAMINATION; ALDEHYDES; OXIDATION; CHEMISTRY; SOLVENT; WATER; KETONES;

D O I：

10.1002/slct.201903856

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalyst-free and regioselective alpha-aminoxylation of 1,3-dicarbonyl compounds with TEMPO by use of Selectfluor as a mild oxidant has been demonstrated, yielding the corresponding alkoxyamines in good to excellent yields. The developed protocol features no employment of a catalyst, broad substrate scope and mild reaction conditions, which enables a convenient and efficient avenue for quaternary C-O bond formation.

引用

页码：12053 / 12056

页数：4

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