Organocatalytic Strategies for the Development of the Enantioselective Inverse-electron-demand Hetero-Diels-Alder Reaction

被引：34
作者：
Laina-Martin, Victor [1 ]
Fernandez-Salas, Jose A. [1 ,2 ]
Aleman, Jose [1 ,2 ]
机构：
[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ Modulo 1, Madrid 28049, Spain
[2] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 49期
关键词：
asymmetric synthesis; cycloadditions; Diels-Alder; heterocycles; organocatalysis; ASYMMETRIC-SYNTHESIS; ALPHA; BETA-UNSATURATED ALDEHYDES; 4+2 CYCLOADDITION; ACTIVATION; KETONES; CONSTRUCTION; CYCLIZATION; CATALYSIS; KETENES;
D O I：
10.1002/chem.202101696
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cycloaddition reactions, in particular Diels-Alder reactions, have attracted a lot of attention from organic chemists since they represent one of the most powerful methodologies for the construction of carbon-carbon bonds. In particular, inverse-electron-demand hetero-Diels-Alder reactions have been an important breakthrough for the synthesis of heterocyclic compounds. Among all their variants, the organocatalytic enantioselective version has been widely explored since the asymmetric construction of diversely functionalized scaffolds under reaction conditions encompassed within the green chemistry field is of great interest. In this review, a profound revision on the latest advances on the organocatalytic asymmetric inverse-electron demand hetero-Diels-Alder reaction is shown.
引用
收藏
页码：12509 / 12520
页数：12
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