Role of immunohistochemistry in the diagnosis and staging of cutaneous squamous-cell carcinomas (Review)

被引：6

作者：

Balasescu, Elena ^{[1
]}

Gheorghe, Andreea-Cristina ^{[1
]}

Moroianu, Andreea ^{[1
,2
]}

Turcu, Gabriela ^{[1
,2
,3
]}

Brinzea, Alice ^{[1
,2
]}

Antohe, Mihaela ^{[1
,2
]}

Hodorogea, Anastasia ^{[1
,2
]}

Manea, Lorena ^{[1
,3
]}

Balaban, Mihaela ^{[2
]}

Andrei, Razvan ^{[4
]}

Hulea, Ionela ^{[1
]}

Popp, Cristiana Gabriela ^{[4
]}

Nichita, Luciana ^{[4
]}

Cioplea, Mirela Daniela ^{[4
]}

Zurac, Sabina Andrada ^{[4
]}

Ion, Daniela Adriana ^{[1
]}

Nedelcu, Roxana Ioana ^{[1
,2
]}

机构：

[1] Carol Davila Univ Medi & Pharm, Natl Inst Infect Dis Prof Dr Matei Bals, Bucharest 021105, Romania

[2] Derma 360 Clinic, Bucharest, Romania

[3] Colentina Clin Hosp, Dept Dermatol, Bucharest 020125, Romania

[4] Colentina Clin Hosp, Dept Pathol, Bucharest 020125, Romania

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2022年 / 23卷 / 06期

关键词：

cutaneous squamous-cell carcinoma; immunohistochemical markers; skin cancer staging; cellular invasion; inflammatory infiltrate; EPITHELIAL-MESENCHYMAL TRANSITION; FOCAL ADHESION KINASE; CD10; EXPRESSION; CANCER; INVASION; P63; ANGIOGENESIS; UTILITY; MARKER; IMMUNOSURVEILLANCE;

D O I：

10.3892/etm.2022.11308

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Non-melanoma skin cancer (NMSC) is the most common type of neoplasm affecting Caucasian individuals, with squamous-cell carcinoma (cSCC) being the second most common type of NMSC after basal-cell carcinoma. The immunohistochemical study of cSCC is of particular importance, especially for the diagnosis of its rare forms, for which accurate and early diagnosis is crucial for survival. In the present review of the literature, the potentially significant value of immunohistochemical markers were highlighted to more accurately assess the biological behaviour, the prognosis of cSCC and to optimize case management. The immunohistochemical markers were classified from a pathophysiological point of view in order to present the mechanism by which carcinogenesis occurs with its subsequent evolution and therefore, to develop a more accurate novel risk staging criteria for this type of neoplasm.

引用

页数：12

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