A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer gels

被引：59
作者：
Kim, SE
Kim, YH
Lee, JJ
Kim, YC
机构：
[1] Korea Res Inst Biosci & Biotechnol, Nat Prod & Biosynthesis Res Unit, Taejon 305600, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期
关键词：
D O I：
10.1021/np9702392
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
引用
收藏
页码：108 / 111
页数：4
相关论文
共 50 条
  • [1] A new sesquiterpene ester from the fruits of Celastrus orbiculatus
    Guo, YQ
    Li, X
    Wang, JH
    Li, W
    Sha, Y
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2003, 5 (03) : 205 - 208
  • [2] A new sesquiterpene ester from the fruits of Celastrus orbiculatus
    Guo, YQ
    Li, X
    Ma, ZJ
    Cui, WS
    Wang, JH
    Ju, ZX
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (02) : 157 - 160
  • [3] A new sesquiterpene ester inhibiting no production from the fruits of Celastrus orbiculatus
    Guo, Y. -Q.
    Li, X.
    Lee, J. -J.
    Xu, J.
    Li, N.
    Meng, D. -L.
    Wang, J. -H.
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2006, 8 (08) : 739 - 742
  • [4] Sesquiterpene esters from Celastrus orbiculatus and their structure-activity relationship on the modulation of multidrug resistance
    Kim, SE
    Kim, HS
    Hong, YS
    Kim, YC
    Lee, JJ
    JOURNAL OF NATURAL PRODUCTS, 1999, 62 (05): : 697 - 700
  • [5] Sesquiterpene esters from the fruits of Celastrus orbiculatus
    Guo, YQ
    Li, X
    Xu, J
    Li, N
    Meng, D
    Wang, JH
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (09) : 1134 - 1136
  • [6] Sesquiterpene esters from the fruits of Celastrus orbiculatus
    Guo, YQ
    Li, X
    Xu, J
    Meng, DL
    Li, YS
    Ohizumi, Y
    CHEMISTRY LETTERS, 2005, 34 (06) : 764 - 765
  • [7] A new sesquiterpene polyol ester from Celastrus angulatus
    Wu, MJ
    Zhao, TZ
    Shang, YJ
    Fu, JG
    Zhang, HY
    CHINESE CHEMICAL LETTERS, 2004, 15 (01) : 41 - 42
  • [8] A New Insecticidal Sesquiterpene Ester from Celastrus Angulatus
    Wei, Shao-peng
    Ji, Zhi-qin
    Zhang, Ji-wen
    MOLECULES, 2009, 14 (04) : 1396 - 1403
  • [9] Identification of a new sesquiterpene ester from Celastrus paniculatus
    Borbone, Nicola
    Borrelli, Francesca
    Montesano, Domenico
    Izzo, Angelo A.
    De Marino, Simona
    Capasso, Raffaele
    Zollo, Franco
    PLANTA MEDICA, 2007, 73 (08) : 792 - 794
  • [10] A New Sesquiterpene Polyol Ester from Celastrus Angulatus
    Ming Jian WU1 *
    Chinese Chemical Letters, 2004, (01) : 41 - 42
12345