Color-tunable AIE-active conjugated polymer nanoparticles as drug carriers for self-indicating cancer therapy via intramolecular FRET mechanism

被引:43
作者
Wang, Ziyu [1 ]
Wang, Cheng [2 ]
Fang, Yayun [1 ]
Yuan, Hong [2 ]
Quan, Yiwu [1 ]
Cheng, Yixiang [1 ]
机构
[1] Nanjing Univ, Sch Chem & Chem Engn, MOE Key Lab Mesoscop Chem, Nanjing 210023, Jiangsu, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
AGGREGATION-INDUCED EMISSION; RESONANCE ENERGY-TRANSFER; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; IN-VITRO; FLUORESCENCE; RECOGNITION; FABRICATION; FLUOROPHORE; TRANSPORT;
D O I
10.1039/c8py00329g
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
In this paper, two novel AIE-active conjugated polymers were synthesized by Pd-catalyzed Suzuki coupling polymerization reaction. Interestingly, the obtained conjugated polymers could exhibit clear color-tunable AIE behavior by adjusting their intramolecular FRET pairs. Among them, P-1 with only one intramolecular FRET pair exhibited clear green-colored AIE fluorescence. As the second intramolecular FRET pair of a TPE moiety and a DTBT moiety was added (P-2), the AIE fluorescence color could be tuned from green to red. The Stokes shift also sharply increased from 125 nm to 255 nm. Furthermore, these AIE-active polymers could form stable conjugated polymer nanoparticles (CPNs) in an aqueous system and act as drug carriers for paclitaxel (PTX). Most importantly, PTX could be sufficiently released from these AIE-active CPNs and showed effective cytotoxicity on HeLa and A549 cells. Especially, these two AIE-active drug carriers were internalized by cells, and they also revealed their location with green or red colored AIE fluorescence. This study can provide a novel strategy for designing color-tunable AIE-active CPN-based drug carriers for self-indicating cancer therapy via changing intramolecular FRET pairs.
引用
收藏
页码:3205 / 3214
页数:10
相关论文
共 64 条
  • [1] Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acidpoly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate
    Abbad, Sarra
    Wang, Cheng
    Waddad, Ayman Yahia
    Lv, Huixia
    Zhou, Jianping
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 : 305 - 320
  • [2] One step emission tunable synthesis of PEG coated Ag2S NIR quantum dots and the development of receptor targeted drug delivery vehicles thereof
    Asik, D.
    Yagci, M. B.
    Duman, F. Demir
    Acar, H. Yagci
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (11) : 1941 - 1950
  • [3] Transport Mechanisms of Solid Lipid Nanoparticles across Caco-2 Cell Monolayers and their Related Cytotoxicology
    Chai, Gui-Hong
    Xu, Yingke
    Chen, Shao-Qing
    Cheng, Bolin
    Hu, Fu-Qiang
    You, Jian
    Du, Yong-Zhong
    Yuan, Hong
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (09) : 5929 - 5940
  • [4] Efficient Light Emitters in the Solid State: Synthesis, Aggregation-Induced Emission, Electroluminescence, and Sensory Properties of Luminogens with Benzene Cores and Multiple Triarylvinyl Peripherals
    Chan, Carrie Y. K.
    Zhao, Zujin
    Lam, Jacky W. Y.
    Liu, Jianzhao
    Chen, Shuming
    Lu, Ping
    Mahtab, Faisal
    Chen, Xiaojun
    Sung, Herman H. Y.
    Kwok, Hoi Sing
    Ma, Yuguang
    Williams, Ian D.
    Wong, Kam Sing
    Tang, Ben Zhong
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2012, 22 (02) : 378 - 389
  • [5] TPGS modified reduced bovine serum albumin nanoparticles as a lipophilic anticancer drug carrier for overcoming multidrug resistance
    Chen, Fangcheng
    Wu, Jun
    Zheng, Chunli
    Zhu, Jiabi
    Zhang, Yajie
    You, Xinru
    Cai, Fujuan
    Shah, Vishva
    Liu, Jianping
    Ge, Liang
    [J]. JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (22) : 3959 - 3968
  • [6] Nanoscale Organic-Inorganic Hybrid Photosensitizers for Highly Effective Photodynamic Cancer Therapy
    Chen, Jia
    Xu, Yu
    Gao, Yu
    Yang, Dongliang
    Wang, Fei
    Zhang, Lei
    Bao, Biqing
    Wang, Lianhui
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2018, 10 (01) : 248 - 255
  • [7] Dual-targeted peptide-conjugated multifunctional fluorescent probe with AIEgen for efficient nucleus-specific imaging and long-term tracing of cancer cells
    Cheng, Yong
    Sun, Chunli
    Ou, Xiaowen
    Liu, Bifeng
    Lou, Xiaoding
    Xia, Fan
    [J]. CHEMICAL SCIENCE, 2017, 8 (06) : 4571 - 4578
  • [8] Two-Step Assembling of Near-Infrared "OFF-ON" Fluorescent Nanohybrids for Synchronous Tumor Imaging and MicroRNA Modulation-Based Therapy
    Deng, Xiongwei
    Yin, Zhaoxia
    Lu, Jianqing
    Xia, Yang
    Shao, Leihou
    Hu, Qin
    Zhou, Zhixiang
    Zhang, Fang
    Zhou, Shaomei
    Wu, Yan
    Sheng, Wang
    Zeng, Yi
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (04) : 3294 - 3305
  • [9] Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications
    Feng, Liheng
    Zhu, Chunlei
    Yuan, Huanxiang
    Liu, Libing
    Lv, Fengting
    Wang, Shu
    [J]. CHEMICAL SOCIETY REVIEWS, 2013, 42 (16) : 6620 - 6633
  • [10] *ZWISCHENMOLEKULARE ENERGIEWANDERUNG UND FLUORESZENZ
    FORSTER, T
    [J]. ANNALEN DER PHYSIK, 1948, 2 (1-2) : 55 - 75