Metal-Free Iodine(III)-Promoted Synthesis of Isoquinolones

被引：49

作者：

Chen, Zhi-Wei

Zhu, Yi-Zhou ^{[1
]}

Ou, Jin-Wang

Wang, Ya-Ping

Zheng, Jian-Yu

机构：

[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, State Key Lab, Tianjin 300071, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 22期

关键词：

N BOND FORMATION; C-H ACTIVATION; INTRAMOLECULAR OXIDATIVE CYCLIZATION; TOPOISOMERASE-I INHIBITORS; MEDIATED ALKYNE AMIDATION; ACID-DERIVATIVES; DIRECTING GROUP; O BOND; ANNULATION; FUNCTIONALIZATION;

D O I：

10.1021/jo5020307

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free oxidative cycloaddition reaction of substituted benzamides and alkynes has been developed for the synthesis of isoquinolones by using bis(trifluoracetoxy)iodobenzene (PIFA) and trifluoroacetic acid (TFA). Under mild conditions, a wide variety of isoquinolones were conveniently prepared via oxidative annulation of simple N-methoxybenzamide and diarylacetylene or aryl/alkyl acetylene derivatives in yields up to 87%.

引用

页码：10988 / 10998

页数：11

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